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Muhamad, Noorzaid
- Anti-Cancer Activity of Aloe Vera Ethanolic Leaves Extract against In vitro Cancer Cells
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Authors
T. Karpagam
1,
Jannathul Firdous
2,
Revathy
1,
Shanmuga Priya
1,
B. Varalakshmi
1,
S. Gomathi
1,
S. Geetha
3,
Noorzaid Muhamad
2
Affiliations
1 Department of Biochemistry, Shrimati Indira Gandhi College, Tiruchirappalli, IN
2 Cluster for Integrative Physiology and Molecular Medicine (CIPMM), Universiti Kuala Lumpur Royal College of Medicine Perak, No.3, Jalan Greentown, 30450, Ipoh, Perak, MY
3 Biochemistry Department, School of Life Sciences, Vels Institute of Science, Technology and Advanced Studies, Pallavaram, Chennai, IN
1 Department of Biochemistry, Shrimati Indira Gandhi College, Tiruchirappalli, IN
2 Cluster for Integrative Physiology and Molecular Medicine (CIPMM), Universiti Kuala Lumpur Royal College of Medicine Perak, No.3, Jalan Greentown, 30450, Ipoh, Perak, MY
3 Biochemistry Department, School of Life Sciences, Vels Institute of Science, Technology and Advanced Studies, Pallavaram, Chennai, IN
Source
Research Journal of Pharmacy and Technology, Vol 12, No 5 (2019), Pagination: 2167-2170Abstract
In the present study, anticancer and cytotoxicity of Aloe vera ethanolic leaves extract was evaluated as the leaves of A.vera are reported to have great medicinal value with potential therapeutic applications. The anticancer activities of the ethanolic leaves extract of A.vera were investigated using 3-(4,5-dimethylthiazole-2yl)-2,5-diphenyl tetrazolium bromide assay on three human cancer cell lines HepG2 (liver cancer), HeLa (human cervical carcinoma cell line) and A549 (human lung adenocarcinoma epithelial cell line).In anticancer studies, A.vera ethanolic leaves extract showed potent proliferation inhibitory activity against HepG2, HeLa and A549 cell lines. The results have shown that the A.vera ethanolic leaves extract contain some active ingredients with the potential of being anticancer agents. A.vera ethanolic leaves extract has the potential to fight against cancer cells. Further work should be carried out on the characterization of specific anticancer components of A.vera.Keywords
Aloe vera, Cancer cell lines, Lipid peroxidation, MTT assay, Phytochemicals.
References
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- Eight Weeks Consumption of High-fat Diet Promotes Mesenteric Fat Deposition When Compared to Other Rat Diets
Abstract Views :81 |
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Authors
Khairil Azwan
1,
Resni Mona
1,
Jannathul Firdous
2,
Dina Keumala Sari
3,
Pamela Rosie David
4,
Noorzaid Muhamad
1
Affiliations
1 Cluster for Integrative Physiology and Molecular Medicine (CIPMM), Faculty of Medicine, Royal College of Medicine Perak, Universiti Kuala Lumpur, Jalan Greentown, 30450 Ipoh, Perak,, MY
2 ,Cluster for Integrative Physiology and Molecular Medicine (CIPMM), Faculty of Medicine, Royal College of Medicine Perak, Universiti Kuala Lumpur, Jalan Greentown, 30450 Ipoh, Perak,, MY
3 Nutrition Department, Faculty of Medicine, Universitas Sumatera Utara,, ID
4 Department of Anatomy, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur,, MY
1 Cluster for Integrative Physiology and Molecular Medicine (CIPMM), Faculty of Medicine, Royal College of Medicine Perak, Universiti Kuala Lumpur, Jalan Greentown, 30450 Ipoh, Perak,, MY
2 ,Cluster for Integrative Physiology and Molecular Medicine (CIPMM), Faculty of Medicine, Royal College of Medicine Perak, Universiti Kuala Lumpur, Jalan Greentown, 30450 Ipoh, Perak,, MY
3 Nutrition Department, Faculty of Medicine, Universitas Sumatera Utara,, ID
4 Department of Anatomy, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur,, MY
Source
Research Journal of Pharmacy and Technology, Vol 15, No 2 (2022), Pagination: 571-574Abstract
Metabolic syndrome is a grouping of several medical conditions plaguing the modern world today. Excessive visceral fat is strongly associated with abdominal obesity which is one of the characteristics of metabolic syndrome. In general, an unbalanced, rich diet plays an important role in the proliferation of adipocytes. Our aim is to observe which diet contributes to the deposition of visceral fat such as the mesenteric fat. For eight weeks, thirty-five Sprague Dawley rats were divided into five groups and were fed five different types of diets. The five diets are normal rat chow, high sugar, high starch, high protein and high fat rat (palm oil-based) feed formula. Besides the formularized rat feeds, the rats were given tap water ad libitum. The result showed high fat diet promotes mesenteric fat proliferation when compared to other rat feed formula. Present study showed that high-fat diet promotes mesenteric fat proliferation when compared to other diets.Keywords
Diet, Enzymes, High-fat, Mesenteric fat, Palm oil.References
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